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The Sound of Evolution
Aflibercept
Mechanism of action:
Aflibercept is a recombinant fusion protein that can bind multiple angiogenesis-related factors, including VEGF-A, VEGF-B, and placental growth factor (PlGF). By preventing these ligands from binding to VEGF receptors (VEGFR-1 and VEGFR-2) on the surface of endothelial cells, aflibercept inhibits neovascular formation and vascular leakage.
Reference(s):
Browning DJ et al. (2012). Aflibercept for age-related macular degeneration: a game-changer or quiet addition? Am J Ophthalmol.
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