The Sound of Evolution
Albendazole
Mechanism of action:
Albendazole binds to β-tubulin in parasitic cells and inhibits microtubule polymerization. This disrupts cytoskeletal function, impairs glucose uptake, and leads to energy depletion, ultimately causing parasite death. Compared with its effects on parasitic cells, its impact on the host cell microtubule system is relatively low.
Reference(s):
1. Lee E et al. (2015). Danazol inhibits cytochrome P450 2J2 activity in a substrate-independent manner. Drug Metab Dispos.
2. Wu Z et al. (2013). CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Antimicrob Agents Chemother.
3. Lee CA et al. (2012). Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos.