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The Sound of Evolution
Albiglutide
Mechanism of action:
Albiglutide mimics the function of glucagon-like peptide-1 (GLP-1). By binding to GLP-1 receptors on pancreatic β cells, it enhances glucose-dependent insulin secretion while also suppressing glucagon release, delaying gastric emptying, and reducing appetite.
Reference(s):
1. Trujillo JM et al. (2014). Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Ann Pharmacother.
2. Lorenz M et al. (2017). Differential effects of glucagon-like peptide-1 receptor agonists on heart rate. Cardiovasc Diabetol.
3. Htike ZZ et al. (2017). Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. Diabetes Obes Metab.
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