top of page
The Sound of Evolution
Alendronate
Mechanism of action:
Alendronate is taken up by osteoclasts and inhibits the function of farnesyl pyrophosphate synthase (FPPS), leading to osteoclast dysfunction and apoptosis. As a result, bone resorption is reduced and bone mineral density increases.
Reference(s):
David P et al. (1996). The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res.
bottom of page