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The Sound of Evolution
Aliskiren
Mechanism of action:
Aliskiren binds to the active site of renin and prevents it from converting angiotensinogen into angiotensin I. Because the production of angiotensin I is reduced, the subsequent formation of angiotensin II also decreases, resulting in lower blood pressure and reduced RAAS-mediated vasoconstriction and aldosterone signaling.
Reference(s):
1. Tsukimoto M et al. (2015). Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys. Biopharm Drug Dispos.
2. FDA. (n.d.). FDA Approved Products: Tekturna (Aliskiren) oral tablets and pellets. FDA.
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