Alitretinoin

Alitretinoin is a retinoid receptor agonist that can activate both retinoic acid receptors (RARs) and retinoid X receptors (RXRs). By binding to these receptors, it regulates gene transcription and the expression of genes involved in cell differentiation, proliferation, and apoptosis, thereby suppressing excessive keratinization and inflammatory responses. In skin cells, it can reduce inflammatory mediators such as IL-1, IL-6, and TNF-α, as well as keratinocyte proliferation, helping to promote skin repair and normalize keratinization.