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Allopurinol


Mechanism of action:

Allopurinol is converted in the body into oxypurinol, which competitively inhibits xanthine oxidase (XO), the enzyme responsible for oxidizing hypoxanthine and xanthine into uric acid. By inhibiting this reaction, allopurinol reduces uric acid production and lowers uric acid concentrations in the blood and urine, thereby helping prevent urate crystal deposition in the joints and kidneys.

Reference(s):

Liang Y et al. (2015). The physiological role of drug transporters. Protein Cell.

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