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The Sound of Evolution
Almotriptan
Mechanism of action:
Almotriptan is a selective 5-HT₁B/₁D receptor agonist. It activates 5-HT₁B receptors on intracranial blood vessels, causing vasoconstriction. It also activates 5-HT₁D receptors on trigeminal nerve endings, thereby inhibiting the release of neuropeptides involved in inflammation and pain transmission, such as calcitonin gene-related peptide (CGRP), substance P, and neurokinin A.
Reference(s):
Salva M et al. (2003). Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos.
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