top of page
The Sound of Evolution
Alosetron
Mechanism of action:
Alosetron is a selective 5-HT₃ receptor antagonist. In the gastrointestinal tract, 5-HT₃ receptors are located in the enteric nervous system and on vagal nerve endings. When excessively activated, these receptors increase intestinal motility, secretion, and visceral pain signaling. By inhibiting 5-HT₃ receptors, Alosetron reduces excessive intestinal activity and visceral hypersensitivity.
Reference(s):
Houghton LA et al. (2001). Alosetron, n 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers. Alimentary Pharmacology & Therapeutics.
bottom of page