Altretamine

Altretamine is an alkylating agent. Its mechanism of action has not been fully clarified, but it is thought to resemble that of other alkylating agents. Altretamine may be metabolized in the liver, particularly by the cytochrome P450 system, into active metabolites. These metabolites may form covalent bonds with guanine or adenine bases in DNA, causing DNA damage and interfering with DNA replication and transcription, thereby inhibiting tumor cell division and inducing apoptosis.