The Sound of Evolution
Ambenonium
Mechanism of action:
Ambenonium is a reversible acetylcholinesterase inhibitor. It inhibits the activity of acetylcholinesterase (AChE) in the synaptic cleft, thereby increasing the concentration of acetylcholine (ACh) at the neuromuscular junction and prolonging its duration of action.
Reference(s):
1. Yamamoto K et al. (1991). Pharmacokinetics of ambenonium, a reversible cholinesterase inhibitor, in rats. Biopharm Drug Dispos.
2. Komloova M et al. (2011). Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors—implications for early myasthenia gravis treatment. Bioorg Med Chem Lett.
3. Liu T et al. (2025). BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data. Nucleic Acids Res.