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The Sound of Evolution
Amikacin
Mechanism of action:
Amikacin binds to the bacterial 30S ribosomal subunit, interferes with the formation of the initiation complex, and causes mRNA misreading and inhibition of protein synthesis.
Reference(s):
Tolmasky ME et al. (2000). Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci.
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