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The Sound of Evolution
Aminoglutethimide
Mechanism of action:
Aminoglutethimide binds to P450scc (cholesterol side-chain cleavage enzyme) and inhibits the conversion of cholesterol to pregnenolone, which is the initiating step in the synthesis of all adrenal corticosteroids. As a result, it reduces the synthesis of cortisol, aldosterone, and sex hormones (androgens and estrogens). It also inhibits aromatase, thereby blocking the conversion of androgens into estrogens.
Reference(s):
1. Santen RJ et al. (1981). Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy.
2. Gross BA et al. (2007). Medical management of Cushing disease. Neurosurg Focus.
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