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The Sound of Evolution
Amiodarone
Mechanism of action:
Amiodarone has a complex mechanism of action and interacts with multiple ion channels and receptors. It is classified as a Vaughan-Williams Class III antiarrhythmic agent. Amiodarone inhibits potassium, sodium, and calcium ion channels, and also has partial beta-receptor blocking activity. Together, these effects prolong the QT interval.
Reference(s):
Kodama I et al. (1999). Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent. Am J Cardiol.
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