Amoxapine

Amoxapine is a tricyclic antidepressant and a dibenzoxazepine derivative. It primarily inhibits norepinephrine reuptake through the norepinephrine transporter, thereby increasing norepinephrine concentration in the synaptic cleft, while its inhibitory effect on the serotonin transporter is relatively weaker. Amoxapine and its active metabolites, especially 8-hydroxyamoxapine, can antagonize dopamine D₂ receptors. It also antagonizes H₁ histamine receptors, muscarinic acetylcholine receptors, and α₁-adrenergic receptors, which contributes to its side effects.