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The Sound of Evolution
Amoxicillin
Mechanism of action:
Amoxicillin binds to penicillin-binding proteins (PBPs) on the bacterial cell membrane and blocks the transpeptidase reaction, preventing cross-linking of peptidoglycan chains. This disrupts the integrity of the bacterial cell wall, causing the bacteria to lyse and die under osmotic pressure.
Reference(s):
1. Jariyawat S et al. (1999). The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther.
2. Li M et al. (2006). Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos.
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