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The Sound of Evolution
Amphotericin B
Mechanism of action:
Amphotericin B is a polyene antifungal agent that preferentially binds to ergosterol in the fungal cell membrane, forming transmembrane pores. This leads to osmotic imbalance, leakage of intracellular contents, and ultimately cell death.
Reference(s):
1. Laniado-Laborin R et al. (2009). Amphotericin B: side effects and toxicity. Rev Iberoam Micol.
2. Baginski M et al. (2009). Amphotericin B and its new derivatives - mode of action. Curr Drug Metab.
3. Baginski M et al. (2005). Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic. Acta Biochim Pol.
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