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The Sound of Evolution
Ampicillin
Mechanism of action:
Ampicillin binds to bacterial penicillin-binding proteins (PBPs), inhibits transpeptidase activity, and blocks cross-linking between peptidoglycan chains. This results in an incomplete cell wall structure, causing the bacteria to swell, rupture, and die under osmotic pressure.
Reference(s):
Li YH et al. (1999). Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model. Int J Pharm.
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