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Amprenavir


Mechanism of action:

Amprenavir binds to the active site of HIV-1 protease, an enzyme responsible for cleaving viral polyprotein precursors (gag and gag-pol polyproteins) into functional enzymatic proteins during viral replication. By blocking this process, amprenavir prevents the formation of these functional proteins, leaving newly produced viral particles immature and noninfectious.

Reference(s):

Karlgren M et al. (2012). In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. Pharm Res.

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