The Sound of Evolution
Anakinra
Mechanism of action:
Anakinra is a recombinant human interleukin-1 receptor antagonist. Its main action is to competitively block the binding of interleukin-1 (IL-1α and IL-1β) to the interleukin-1 type I receptor (IL-1RI) on the cell surface, thereby inhibiting IL-1-mediated inflammatory responses.
Reference(s):
1. Tang YH et al. (2007). Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1 beta, its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats. Zhong Xi Yi Jie He Xue Bao.
2. Dayer JM et al. (2003). The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis. Rheumatology (Oxford).
3. Vamvakopoulos J et al. (2002). Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist. Eur J Immunol.