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The Sound of Evolution
Anidulafungin
Mechanism of action:
Anidulafungin is an echinocandin derivative. It acts by noncompetitively inhibiting 1,3-β-D-glucan synthase in the fungal cell wall, thereby blocking the synthesis of 1,3-β-D-glucan. Since this glucan is a major structural component of the fungal cell wall, anidulafungin weakens the cell wall, causes osmotic instability, and leads to fungal cell swelling and rupture.
Reference(s):
1. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
2. Sucher AJ et al. (2009). Echinocandins: the newest class of antifungals. Ann Pharmacother.
3. Morris MI et al. (2006). Echinocandins in the management of invasive fungal infections, part 1. Am J Health Syst Pharm.
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