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The Sound of Evolution
Aprepitant
Mechanism of action:
Aprepitant is a selective neurokinin-1 (NK1) receptor antagonist. It works by blocking neurokinin-1 receptors in the central and peripheral nervous systems, thereby preventing substance P from binding to these receptors.
Reference(s):
1. Dando TM et al. (2004). Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs.
2. Navari RM et al. (2004). Aprepitant: a neurokinin-1 receptor antagonist for the treatment of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther.
3. Sanchez RI et al. (2004). Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos.
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