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Arformoterol


Mechanism of action:

Arformoterol is a selective long-acting β₂-adrenergic receptor agonist. Arformoterol binds to β₂-adrenergic receptors on the membrane of bronchial smooth muscle cells, activating adenylyl cyclase and increasing intracellular cAMP levels. This subsequently activates protein kinase A (PKA), lowers cytosolic Ca²⁺ concentration, and promotes smooth muscle relaxation. The final result is relaxation of bronchial smooth muscle and bronchodilation.

Reference(s):

1. Somers GI et al. (2007). A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 


2. Zhang M et al. (2000). Stereoselective glucuronidation of formoterol by human liver microsomes. Br J Clin Pharmacol.

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