The Sound of Evolution
Ascorbic acid
Mechanism of action:
Ascorbic acid is a water-soluble vitamin and a potent antioxidant. During collagen synthesis, ascorbic acid serves as a cofactor for prolyl/lysyl hydroxylase, which converts proline and lysine residues into hydroxyproline and hydroxylysine. These hydroxylation reactions are essential for stabilizing the triple-helical structure of collagen and maintaining its cross-linking strength. In addition, ascorbic acid donates electrons to neutralize free radicals, thereby protecting cell membranes, DNA, and proteins from oxidative damage. It also reduces ferric iron (Fe³⁺) in the intestine to ferrous iron (Fe²⁺), improving the absorption of non-heme iron.
Reference(s):
1. Padayatty SJ et al. (2003). Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr.
2. Meister A et al. (1994). Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem.
3. Englard S et al. (1986). The biochemical functions of ascorbic acid. Annu Rev Nutr.