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The Sound of Evolution
Atazanavir
Mechanism of action:
Atazanavir binds to the active site of HIV-1 protease. During viral replication, this protease is responsible for cleaving viral polyprotein precursors, including gag and gag-pol polyproteins, into functional enzymatic proteins. Atazanavir prevents the formation of these mature proteins, causing newly produced viral particles to remain immature and noninfectious.
Reference(s):
1. Croom KF et al. (2009). Atazanavir: a review of its use in the management of HIV-1 infection. Drugs.
2. von Hentig N et al. (2008). Atazanavir/ritonavir: a review of its use in HIV therapy. Drugs Today (Barc).
3. Swainston Harrison T et al. (2005). Atazanavir: a review of its use in the management of HIV infection. Drugs.
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