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The Sound of Evolution
Atovaquone
Mechanism of action:
Atovaquone primarily acts on the mitochondrial electron transport chain. It inhibits the cytochrome bc₁ complex (complex III) in protozoan mitochondria, thereby blocking electron transport and oxidative phosphorylation. This results in impaired ATP production and cellular energy depletion.
Reference(s):
1. Pai MP et al. (2018). Drug interactions in infectious diseases: antimicrobial drug interactions (4th ed.). Springer.
2. Piscitelli S et al. (2011). Drug interactions in infectious diseases (3rd ed.). Springer Science.
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