The Sound of Evolution
Aztreonam
Mechanism of action:
Aztreonam is a monobactam antibiotic that acts against Gram-negative bacteria. It binds to penicillin-binding proteins (PBPs) in Gram-negative bacteria, especially PBP-3, thereby inhibiting the cross-linking of cell wall peptidoglycan and blocking bacterial cell wall synthesis. When the bacterial cell wall loses its integrity, osmotic imbalance occurs, ultimately causing bacterial lysis and death.
Reference(s):
1. Rittenbury MS et al. (1990). How and why aztreonam works. Surg Gynecol Obstet.
2. Mock CN et al. (1995). Clinical significance of antibiotic endotoxin-releasing properties in trauma patients. Arch Surg.
3. Fung-Tomc J et al. (1997). Antibacterial activity of BMS-180680, a new catechol-containing monobactam. Antimicrob Agents Chemother.