The Sound of Evolution
Beclomethasone
Mechanism of action:
Beclomethasone is a synthetic glucocorticoid. It suppresses inflammatory responses through activation of the intracellular glucocorticoid receptor (GR), regulating gene expression and inhibiting the transcription of pro-inflammatory genes such as IL-1, IL-6, TNF-α, and COX-2.
Reference(s):
1. Daley-Yates PT et al. (2001). Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man. Br J Clin Pharmacol.
2. Brogden RN et al. (1984). Beclomethasone dipropionate: a reappraisal of its pharmacodynamic properties and therapeutic efficacy after a decade of use in asthma and rhinitis. Drugs.
3. Edwards TB et al. (1995). Effectiveness and safety of beclomethasone dipropionate, an intranasal corticosteroid, in the treatment of patients with allergic rhinitis. Clin Ther.