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The Sound of Evolution
Benznidazole
Mechanism of action:
Benznidazole is a nitroimidazole derivative that acts against protozoa such as Trypanosoma cruzi. Within T. cruzi cells, benznidazole is activated by nitroreductase to form nitro radicals. These radicals interact with the parasite's DNA, RNA, and proteins, causing molecular damage that impairs parasite survival and ultimately leads to death.
Reference(s):
1. Maya JD et al. (2007). Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host. Comp Biochem Physiol A Mol Integr Physiol.
2. Rajao MA et al. (2014). Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi. Environ Mol Mutagen.
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