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The Sound of Evolution
Benzocaine
Mechanism of action:
Benzocaine is an ester derivative of para-aminobenzoic acid (PABA). It acts by reversibly blocking voltage-gated Na⁺ channels on neuronal cell membranes, preventing Na⁺ influx. This blocks neuronal depolarization and the generation and conduction of action potentials, resulting in local loss of sensation.
Reference(s):
1. Hartman NR et al. (2014). More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems. Regul Toxicol Pharmacol.
2. Becker DE et al. (2006). Essentials of local anesthetic pharmacology. Anesth Prog.
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