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The Sound of Evolution
Benzonatate
Mechanism of action:
Benzonatate can bind to voltage-gated Na⁺ channels on neuronal cell membranes, keeping the sodium channels in an inactivated state and preventing Na⁺ influx that would otherwise produce depolarization. As a result, action potentials cannot be generated, sensory nerves become anesthetized, and the sensitivity of the cough reflex is reduced.
Reference(s):
1. Dicpinigaitis PV et al. (2009). Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough. Respir Med.
2. Bishop-Freeman SC et al. (2017). Benzonatate toxicity: nothing to cough at. J Anal Toxicol.
3. Thimann DA et al. (2012). Benzonatate toxicity in a teenager resulting in coma, seizures, and severe metabolic acidosis. J Pediatr Pharmacol Ther.
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