The Sound of Evolution
Benztropine
Mechanism of action:
Benztropine is an anticholinergic agent that also has antihistaminic H1 activity and mild dopamine reuptake inhibitory effects. It acts as an antagonist of central M1 muscarinic acetylcholine receptors. By blocking M1 receptors, benztropine suppresses excessive cholinergic excitation and helps regulate the balance between acetylcholine and dopamine, influencing neural pathways related to tremor and abnormal muscle tone. In addition, benztropine can mildly inhibit the dopamine transporter, reducing dopamine reuptake and increasing synaptic dopamine concentration, thereby affecting neurotransmission related to Parkinson's disease symptoms.
Reference(s):
1. Rothman RB et al. (2008). Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochem Pharmacol.
2. Reith ME et al. (2015). Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter. Drug Alcohol Depend.