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The Sound of Evolution
Besifloxacin
Mechanism of action:
Besifloxacin is a fourth-generation fluoroquinolone antibiotic. It binds to the DNA gyrase complex (DNA gyrase, the bacterial topoisomerase II) and prevents the enzyme from rejoining DNA strands, leading to bacterial DNA breaks. Besifloxacin also inhibits the activity of topoisomerase IV, thereby preventing proper separation and replication of bacterial DNA.
Reference(s):
1. O'Brien TP et al. (2012). Besifloxacin ophthalmic suspension, 0.6%: a novel topical fluoroquinolone for bacterial conjunctivitis. Adv Ther.
2. Proksch JW et al. (2009). Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans. J Ocul Pharmacol Ther.
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