The Sound of Evolution
Betamethasone
Mechanism of action:
Betamethasone is a synthetic glucocorticoid. After crossing the cell membrane, it binds to the glucocorticoid receptor (GR), promoting the expression of anti-inflammatory genes such as IL-10 and IκB-α, while suppressing the expression of pro-inflammatory genes such as IL-1, IL-6, TNF-α, and COX-2. Through this gene regulatory mechanism, it suppresses inflammation-related responses.
Reference(s):
1. Czock D et al. (2005). Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet.
2. Uva L et al. (2012). Mechanisms of action of topical corticosteroids in psoriasis. Int J Endocrinol.
3. Spada F et al. (2018). Comparative safety and efficacy of topical mometasone furoate with other topical corticosteroids. Australas J Dermatol.