The Sound of Evolution
Betaxolol
Mechanism of action:
Betaxolol is a selective β1-adrenergic receptor blocker. It selectively blocks β1 receptors in the heart, suppressing the rapid heartbeat caused by sympathetic stimulation and thereby reducing heart rate and contractility. By blocking β1 receptors in the kidney, it also reduces the activity of the renin-angiotensin-aldosterone system (RAAS), leading to vasodilation and increased sodium excretion, thereby influencing blood pressure regulation. In the eye, it blocks β1 receptors in the ciliary body, suppressing aqueous humor production and thereby affecting intraocular pressure.
Reference(s):
Canotilho J et al. (2010). The structure of betaxolol studied by infrared spectroscopy and natural bond orbital theory. Spectrochim Acta A Mol Biomol Spectrosc.