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The Sound of Evolution
Betrixaban
Mechanism of action:
Betrixaban is a factor Xa inhibitor. Betrixaban reversibly inhibits the activity of factor Xa, preventing the conversion of prothrombin to thrombin, thereby inhibiting fibrin formation and ultimately reducing the likelihood of thrombus formation.
Reference(s):
1. Turpie AG et al. (2008). New oral anticoagulants in atrial fibrillation. Eur Heart J.
2. Connolly SJ et al. (2013). Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa). Eur Heart J.
3. Zhang P et al. (2009). Discovery of betrixaban (PRT054021), a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett.
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