The Sound of Evolution
Bimatoprost
Mechanism of action:
Bimatoprost is a derivative of prostaglandin F₂α (PGF₂α). Bimatoprost activates prostaglandin F receptors in the ciliary muscle and aqueous humor outflow pathways, thereby altering the structure of the extracellular matrix, reducing outflow resistance, and increasing aqueous humor drainage through the scleral pathway. It may also affect aqueous humor drainage through Schlemm's canal. Bimatoprost also regulates proliferation- and differentiation-related processes in hair follicle cells through prostaglandin F receptors.
Reference(s):
1. Chen MJ et al. (2006). Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma. J Ocul Pharmacol Ther.
2. Kruse P et al. (2006). Cystoid macular edema in a pseudophakic patient after several glaucoma procedures: is local therapy with bimatoprost the reason? Klin Monbl Augenheilkd.
3. Steinhauser SL et al. (2006). Decreased high-density lipoprotein serum levels associated with topical bimatoprost therapy. Optometry.