The Sound of Evolution
Biperiden
Mechanism of action:
Biperiden is a muscarinic acetylcholine receptor antagonist. Biperiden primarily blocks M₁ receptors, reducing acetylcholine stimulation and restoring the dopamine/acetylcholine balance, thereby decreasing the excitability of neural circuits associated with tremor.
Reference(s):
1. Nishiyama K et al. (1993). Chronic dementia in Parkinson's disease treated by anticholinergic agents: neuropsychological and neuroradiological examination. Adv Neurol.
2. Hosoi R et al. (1999). Evaluation of in vivo binding properties of ³H-NMPB and ³H-QNB in mouse brain. J Neural Transm (Vienna).
3. Pehl C et al. (1998). Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther.