The Sound of Evolution
Bisoprolol
Mechanism of action:
Bisoprolol is a selective β₁-adrenergic receptor blocker. Bisoprolol primarily blocks β₁ receptors in the myocardium and sinoatrial node, slowing heart rate, reducing contractility, decreasing cardiac oxygen demand, and lowering cardiac output. Bisoprolol also blocks β₁ receptors on juxtaglomerular cells in the kidney, reducing renin release and thereby decreasing the activity of the renin-angiotensin-aldosterone system (RAAS), which in turn affects blood pressure regulation.
Reference(s):
1. Lancaster SG et al. (1988). Bisoprolol: A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris. Drugs.
2. Ishiguro H et al. (2008). Antiarrhythmic effect of bisoprolol, a highly selective beta1-blocker, in patients with paroxysmal atrial fibrillation. Int Heart J.
3. Metra M et al. (2007). Bisoprolol in the treatment of chronic heart failure: from pathophysiology to clinical pharmacology and trial results. Ther Clin Risk Manag.