The Sound of Evolution
Bivalirudin
Mechanism of action:
Bivalirudin is a direct thrombin inhibitor that reversibly inhibits the activity of thrombin. Bivalirudin binds to the active site of thrombin, preventing thrombin from converting fibrinogen into fibrin. It also binds to the fibrinogen-binding site (exosite I), preventing thrombin from attaching to the thrombus surface and thereby reducing the likelihood of new thrombus formation and expansion of existing thrombi.
Reference(s):
1. Seybert AL et al. (2006). Treatment of heparin-induced thrombocytopenia: is there a role for bivalirudin? Pharmacotherapy.
2. Dager WE et al. (2007). Heparin-induced thrombocytopenia: treatment options and special considerations. Pharmacotherapy.
3. Dang CH et al. (2006). Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia. Pharmacotherapy.