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The Sound of Evolution
Brinzolamide
Mechanism of action:
Brinzolamide is a carbonic anhydrase inhibitor. In the epithelial cells of the ciliary processes, carbonic anhydrase II participates in aqueous humor production. Brinzolamide inhibits the activity of carbonic anhydrase II, thereby decreasing aqueous humor secretion and consequently affecting intraocular pressure.
Reference(s):
1. Iester M et al. (2004). Retinal peripapillary blood flow before and after topical brinzolamide. Ophthalmologica.
2. Kaup M et al. (2004). Effects of brinzolamide on ocular haemodynamics in healthy volunteers. Br J Ophthalmol.
3. Iester M et al. (2008). Brinzolamide ophthalmic suspension: a review of its pharmacology and use in the treatment of open angle glaucoma and ocular hypertension. Clin Ophthalmol.
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