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Brivudine


Mechanism of action:

Brivudine is a thymidine analog. Brivudine itself is a prodrug. After entering infected cells, it is phosphorylated by viral thymidine kinase into brivudine monophosphate, and is then further converted by other host cell kinases into brivudine triphosphate. Brivudine triphosphate competitively inhibits viral DNA polymerase and can also be incorporated into viral DNA, thereby disrupting replication and preventing viral proliferation.

Reference(s):

Solaroli N et al. (2008). Substrate specificity of feline and canine herpesvirus thymidine kinase. Antiviral Res.

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