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The Sound of Evolution
Brompheniramine
Mechanism of action:
Brompheniramine is a first-generation H₁ receptor antagonist belonging to the alkylamine class. Brompheniramine binds to H₁ receptors and blocks the physiological effects associated with histamine-induced allergic reactions. In addition, brompheniramine primarily blocks central and peripheral muscarinic acetylcholine receptors, including M₁ to M₃, thereby reducing glandular secretions such as dry mouth and dry nasal passages, and it also has mild sedative and drowsiness-related effects.
Reference(s):
Yasuda SU et al. (1999). Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy.
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