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The Sound of Evolution
Budesonide
Mechanism of action:
Budesonide is a synthetic glucocorticoid. After entering the cytoplasm, budesonide binds to the glucocorticoid receptor (GR) to form a complex, which then translocates into the nucleus and regulates the expression of immune-related genes. For example, it promotes the expression of anti-inflammatory genes such as Annexin A1 and IL-10, while suppressing the expression of inflammatory genes such as IL-1, IL-6, TNF-α, and COX-2.
Reference(s):
1. Gardill BR et al. (2012). Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One.
2. Czock D et al. (2005). Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet.
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