top of page
The Sound of Evolution
Bupropion
Mechanism of action:
Bupropion is a norepinephrine-dopamine reuptake inhibitor. It blocks the reuptake functions of the norepinephrine transporter and dopamine transporter on the presynaptic membrane, increasing synaptic concentrations of norepinephrine and dopamine. This in turn influences neural transmission involved in attention, mood, and addiction-related neural circuits.
Reference(s):
1. Fryer JD et al. (1999). Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine. J Pharmacol Exp Ther.
2. Fava M et al. (2005). 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry.
bottom of page