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The Sound of Evolution
Cabergoline
Mechanism of action:
Cabergoline is a long-acting dopamine D₂ receptor agonist and an ergot derivative. Cabergoline activates D₂ receptors in the pituitary gland, inhibits adenylate cyclase, reduces cAMP levels, and lowers prolactin production and release. In addition, cabergoline activates D₂ receptors in the nigrostriatal pathway, enhancing dopamine signaling and modulating neural circuit transmission involved in motor control.
Reference(s):
1. Pastor P et al. (2003). Cabergoline in the treatment of Parkinson's disease. Neurologia.
2. Curran MP et al. (2004). Cabergoline: a review of its use in the treatment of Parkinson's disease. Drugs.
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