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The Sound of Evolution
Capreomycin
Mechanism of action:
Capreomycin is a cyclic peptide antibiotic. Capreomycin binds to the 70S ribosomal complex of Mycobacterium tuberculosis at the interface between the 50S and 30S subunits, blocking translocation and peptide chain elongation during translation. Because bacterial protein synthesis is inhibited, the bacteria are unable to grow.
Reference(s):
1. Fu LM et al. (2007). Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide GeneChips. J Infect.
2. Johansen SK et al. (2006). Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Mol Cell.
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