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The Sound of Evolution
Carbamazepine
Mechanism of action:
Carbamazepine is a dibenzazepine derivative. Carbamazepine binds to voltage-gated Na+ channels on neuronal membranes, stabilizes their inactivated state, and prevents excessive repetitive opening and the generation of high-frequency action potentials.
Reference(s):
1. Staines AG et al. (2004). N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7. J Pharmacol Exp Ther.
2. Sisodiya SM et al. (2007). Drug resistance in epilepsy: more twists in the tale. Epilepsia.
3. Tolou-Ghamari Z et al. (2013). A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. J Res Med Sci.
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