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The Sound of Evolution
Carbenicillin
Mechanism of action:
Carbenicillin is a beta-lactam antibiotic belonging to the carboxypenicillin class. Carbenicillin binds to bacterial penicillin-binding proteins (PBPs) and inhibits transpeptidase activity, preventing cross-linking of peptidoglycan. As a result, the bacterial cell wall becomes incomplete, and the bacteria rupture and die under osmotic pressure.
Reference(s):
1. Sainsbury S et al. (2011). Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms. J Mol Biol.
2. Ishii Y et al. (1995). Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from Escherichia coli. Antimicrob Agents Chemother.
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