The Sound of Evolution
Carboplatin
Mechanism of action:
Carboplatin is a structurally modified second-generation derivative of cisplatin. Inside the cell, carboplatin undergoes aquation to release active platinum ions (Pt2+), which bind to DNA bases, especially the N7 position of guanine, forming intrastrand and interstrand cross-links. These cross-links prevent normal DNA replication and transcription, may arrest the cell cycle at the G2/M phase, and trigger DNA damage responses and cell death-related pathways.
Reference(s):
1. Knox RJ et al. (1986). Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA. Cancer Res.
2. Sooriyaarachchi M et al. (2011). Comparative hydrolysis and plasma protein binding of cis-platin and carboplatin in human plasma in vitro. Metallomics.